A global burden

Iron deficiency is the most common nutritional challenge in the world, in developed and developing countries alike. According to the World Health Organization, more than 2 billion people across the globe suffer from iron-deficiency anemia. The highest prevalence is seen in children, followed by pregnant women and women of reproductive age, of whom approximately 30% are anemic.

The primary causes of iron-deficiency anemia are inadequate dietary iron and infectious diseases, such as malaria. Deficiencies are common in vegetarians and vegans; intake and bodily iron stores are often insufficient to meet the needs, which is also true for athletes and pregnant women. Women are at a greater risk for iron deficiency than are men, due to the monthly menstrual cycle.

Many types of iron supplements are currently available; however, the body is only able to absorb 10-20% of supplemental iron, regardless of the formulation. Unabsorbed iron ends up in the intestines, where it may cause side effects such as constipation, abdominal pain, and disturbances in the composition of the gut bacteria.

Demands a novel approach

Iron deficiency can result in frequent headaches, fatigue, loss of energy, and impaired capacity in daily life. For many people, experiencing the positive physical effects of improved iron status is a strong incentive to take supplements. For athletes, the restoration of iron stores can positively affect physical performance, especially during high endurance sports.

The majority of women are aware of the importance of iron, especially when planning for and during pregnancy. Many vegans, vegetarians, and athletes are also concerned about their iron status, often turning to supplements to ensure that their needs are met. However, the side effects associated with conventional iron supplements often lead consumers to stop taking them.

While most consumers are aware of the link between gastrointestinal and overall health, many are unaware of the negative effects on the gut microbiota of high levels of iron. A probiotic supplement that simultaneously improves iron absorption and supports gastrointestinal health—without side effects—is ideal.