Strong bones are key to an active life – probiotics to play a role

Probi^® is entering into a three-years collaboration with researchers at La Trobe University in Australia studying bone health.

The collaboration will include a clinical trial that is aiming to investigate the effect of Probi^® Osteo in an Australian female population. Supported by novel techniques, the modulatory role of the gut microbiome and Probi Osteo will be further explored on bone metabolism, microarchitecture and density.

Heading the research group in Australia is Associate Professor George Moschonis, La Trobe University, who is an internationally recognized leader in nutrition research.

Dr Moschonis said: “recent scientific evidence has consistently highlighted the important role of the gut microbiome on bone health. Considering these breakthrough discoveries, we are excited to contribute our strengths into further extending the current knowledge and produce additional high-quality research evidence  that will shed more light on the effectiveness of probiotics in the reduction of bone loss”.

Bone loss after the age of 30

After the age of 30, bone loss exceeds bone formation, resulting in a gradual loss of bone density. For women, bone resorption – and consequently bone loss – accelerates, as estrogen levels decline during menopause. This acceleration increases the risk of osteoporosis and resulting fractures.

Probi study showed 78% decreased bone loss compared to placebo

Probi already launched the Probi^® Osteo concept in 2018, based upon the combination of Lactiplantibacillus plantarum HEAL9 (HEAL9™), Lactiplantibacillus plantarum HEAL19, and Lacticaseibacillus paracasei 8700:2. Probi Osteo is clinically proven to maintain healthy bones in a randomized, placebo-controlled, double-blind study of 249 healthy women aged 47–69 years. The clinical study showed 78% decreased bone loss compared to placebo, and the study was published in The Lancet.

Titti Niskanen, Director R&D & Clinical Operations at Probi^® comments: “We have excellent clinical results from our 2018 study, and now the time has come to repeat the study. We work closely with international partners and academic groups to conduct state-of-the-art clinical trials and we confirm our findings and the health effects by multiple studies. With this collaboration we aim to continue and expand our research in the bone health area – an area where Probi has done pioneering work and has earlier completed a successful clinical trial showing significantly reduced bone loss by taking Probi^® Osteo”.

“Bone health is a relatively new area within probiotics, and in alignment with Probi’s mission of being “First in Probiotics”, this collaboration proves our dedication to document our products in multiple clinical trials and our curiosity in understanding the mechanisms by which our probiotic strains can exert their beneficial effects”, adds Tom Rönnlund, CEO, Probi.

For further information, please contact:

Titti Niskanen, Director R&D & Clinical Operations, Probi^®
Phone: +46 46 286 89 68, E-mail: titti.niskanen@probi.com

Tom Rönnlund, CEO, Probi^®
Phone: +46 46 286 89 40, E-mail: trd@probi.com

Charlotte Beyerholm, Director Marketing & Global Communication, Probi^®
Phone: +46 76 870 94 65, E-mail: charlotte.beyerholm@probi.com

ABOUT PROBI

Probi^® is a global company focused exclusively on researching, manufacturing, and delivering probiotics for supplements and functional food. We are experts at managing stable, live bacteria from R&D through every stage of the manufacturing process and are dedicated to making the health-enhancing benefits of probiotics available to people everywhere. Our health concepts, formulations, and formats are supported by robust clinical documentation. Since our founding in 1991 at Sweden’s Lund University, Probi has expanded its operations to more than 40 markets. We hold more than 400 patents globally.

ABOUT LA TROBE

For more than 50 years, La Trobe University has been transforming people and societies and has earned a global reputation for research that addresses the major issues of our time. With a dual emphasis on excellence and diversity, La Trobe has seven campuses across Victoria and New South Wales. Through innovations in teaching and learning, strong graduate employment outcomes and commitment to quality and breakthrough research, La Trobe consistently rates among the world’s best.